269 papers
By comparing early mouse and human forebrains using single-cell transcriptomics and 3D spatial imaging, this study reveals that human-specific telencephalic patterning initiates as early as the fourth post-conception week through delayed ventral SHH signaling and an anterior FGF signature, which collectively drive distinct progenitor identity allocation and reduced diversity compared to mice.
This study reveals that the male bias in medulloblastoma is primarily driven by prenatal developmental factors and the presence of male gonadal hormones, specifically testosterone, which increase the abundance and proliferation of cerebellar progenitors susceptible to tumor formation.
This study constructs a single-cell atlas of postnatal human lung development to identify temporally regulated gene expression patterns, revealing that genetic susceptibility to chronic lung diseases like COPD is linked to specific windows of vulnerability during early postnatal vascular maturation.
This study demonstrates that the long-term trajectory of intestinal aging and homeostasis in *Drosophila* is established early during development, as genetic modulation of cellular aging pathways in larval adult midgut progenitors dictates adult gut function, lineage balance, and regenerative capacity.
This study reveals that key actin-related proteins exhibit asymmetric intracellular distributions and differential segregation mechanisms during the early *C. elegans* embryonic stages (zygote to 4-cell), adding a new layer of complexity to the understanding of cell fate acquisition and embryonic polarity.
This paper introduces KELPE, a novel embryonic stem cell line featuring two silencing-resistant genomic landing pads that enables efficient prototyping and fair comparison of synthetic gene circuits, such as optimized cell-cell interaction reporters and inducible cell death systems, within a developmentally relevant model.
The paper introduces ZMAP, a harmonized single-cell meta-atlas integrating nearly 800,000 zebrafish embryonic cells from eight studies to establish a consensus hierarchy of cell identities, standardized marker genes, and accessible tools for automated annotation and interactive exploration.
This study reveals that spiny mice possess a unique, honeycomb-like fracture lattice composed of collagen VI and driven by spiny hairs, which enables controlled skin autotomy while simultaneously dampening inflammation and promoting rapid tissue regeneration.
This study reveals that P-body factors Ddx6 and Ddx61 compensate for the loss of mRNA decay in *pnrc2* mutants by regulating the translation of accumulated, deadenylated transcripts, thereby ensuring normal embryonic development despite defective mRNA turnover.
This study demonstrates that the sulfation of PSY peptides by TPST is essential for cell expansion and development in the non-vascular plant *Physcomitrium patens*, revealing that this sulfated peptide signaling mechanism is evolutionarily conserved across land plants.
This study reveals that in horned beetles, trait-specific chromatin architectures and differential binding of the transcription factor ventral veinless, alongside sex-specific isoforms of doublesex, channel pleiotropic genes to generate mosaic patterns of sexual dimorphism across different tissues.
This study demonstrates that the ability of the pioneer factor ASCL1 to drive coherent neuronal differentiation is not solely determined by its binding capacity but is strictly dependent on developmental context, requiring both chromatin priming with permissive histone marks and the presence of specific co-factors like PHOX2B to ensure appropriate lineage specification.
This study demonstrates that while early anterior neural identity can arise autonomously and requires planar signals from the node for specification and anterior-posterior patterning, long-term maintenance of this identity depends on vertical signals from the axial mesendoderm.
This study reveals that the transcription factor Tead4 preferentially localizes to large, high-membrane-potential mitochondria in 8-cell mouse embryos, establishing a developmentally regulated mitochondrial basis for controlling Tead4 bioavailability during the first mammalian cell fate decision.
This study utilizes a novel atoh7:iCre;ubi:Switch lineage tracing system in zebrafish to demonstrate that while 79% of retinal ganglion cells originate from atoh7-positive progenitors, a significant atoh7-negative RGC population exists, providing a model to investigate RGC survival mechanisms and cell fate plasticity.
Maternal hyperglycemia drives placental insufficiency and fetal growth restriction by inducing ACLY-dependent acetyl-CoA production, which triggers global histone hyperacetylation and epigenetic reprogramming that represses pro-proliferative pathways despite systemic nutrient abundance.
This study introduces a novel imaging-based approach combining HCR-FISH and live imaging to characterize Enhancer RNA (eRNA) transcription in Drosophila embryos, revealing that eRNA production is promoter-independent, influenced by insulators, and driven by local regulatory contexts rather than strict enhancer boundaries.
This study demonstrates that IFN-γ-dependent macrophage reprogramming is essential for coordinating inflammatory resolution and extracellular matrix remodeling to drive successful heart regeneration in zebrafish.
This study demonstrates that using HyperBull, a novel sperm capacitation technology, significantly improves the hatching rates of bovine embryos produced via in vitro fertilization compared to conventional heparin-based methods, suggesting enhanced embryonic developmental competence and implantation readiness.
This study demonstrates that in *Xenopus laevis*, fibronectin orchestrates the assembly of the extracellular matrix and the multilayered organization of second heart field progenitor cells within the dorsal pericardial wall, thereby ensuring proper cardiac outflow tract elongation and ventricular development.